Table 3 The observations of micronucleus after administered once on the day of 2nd oral administration of 23%-GNANA, a test substance to the male mice (n=25)

Dose(mg/kg)	Animal#	MNPCE observed	MNPCE /2,000 PCE (%)	PCEcounted	PCE/200 RBC (%)
0(D.W.)	1101	3	0.15	81	40.5
	1102	3	0.15	84	42.0
	1103	3	0.10	77	38.5
	1104	2	0.10	83	41.5
	1105	3	0.10	82	41.0
	Mean±S.D.	2.6±0.56*	0.13±0.027*	81.4±2.70*	40.7±1.35*
500	1201	3	0.15	81	40.5
	1202	3	0.15	81	40.5
	1203	3	0.15	76	38.0
	1204	4	0.20	84	42.0
	1205	2	0.10	80	40.0
	Mean±S.D.	3.0±0.71	0.15±0.035	80.4±2.88	40.2±1.44
1,000	1301	2	0.10	77	38.5
	1302	3	0.15	81	40.5
	1303	3	0.15	77	38.5
	1304	3	0.15	82	41.0
	1305	3	0.15	80	40.0
	Mean±S.D.	2.8±0.45	0.14±0.022	79.4±2.90	39.7±115
2,000	1401	2	0.10	80	40.0
	1402	2	0.10	78	39.0
	1403	3	0.15	80	40.0
	1404	2	0.10	84	42.0
	1405	4	0.20	77	38.5
	Mean±S.D.	2.6±0.89	0.13±0.045	79.86±2.68	39.9±1.34
2(MMC)	1501	32	1.60	87	43.5
	1502	32	1.60	85	42.5
	1503	31	1.55	83	41.5
	1504	32	1.60	85	42.5
	1505	35	1.75	81	40.5
	Mean±S.D.	32.4±1.52	1.62±0.078	84.2±2.28	42.1±1.14

MNPCE: Micronucleated polychromatic erythrocyte, PCE: Polychromatic erythrocyte, RBC: Red blood cells (polychromaric erythrocyte + normochromatic erythrocyte), MMC: Mitomycin C
^*: Significantly different from the vehicle control group at p<0.05