Table 15 An assessment of the changes in relative organ weights (% of body weight) affected by the 90-day oral administration of 23%-GNANA, a test substance to the male and female rats (n=10)

Organ weight(g)**	Groups (mg/kg/day)a)
	G1 (0)%		G2 (1,250)		G3 (2,500)		G4 (5,000)
	Male	Female	Male	Female	Male	Female	Male	Female
Adrenal(L)	0.0058±0.00099*#	0.0139±0.00082*	0.0054±0.00075	0.0137±0.00238	0.0053±0.00105	0.0139±0.00223	0.0055±0.00093	0.0137±0.00193
Adrenal(R)	0.0055±0.00084	0.0136±0.00158	0.0052±0.00094	0.0143±0.00173	0.0050±0.00074	0.0138±0.00257	0.0053±0.00094	0.0123±0.00401
Pituitary	0.0027±0.00028	0.0057±0.00089	0.0028±0.00038	0.0064±0.00111	0.0027±0.00027	0.0057±0.00044	0.0029±0.00034	0.0061±0.00081
Thymus	0.0964±0.01332	0.1164±0.03328	0.1012±0.03337	0.1348±0.02560	0.0961±0.02014	0.1210±0.03353	0.0994±0.01883	0.1128±0.01433
Ovary(L)		0.0240±0.00612		0.0272±0.00335		0.0249±0.00309		0.0270±0.00520
Ovary(R)		0.0235±0.00247		0.0267±0.00387		0.0263±0.00318		0.0254±0.00351
Prostate	0.1324±0.02611		0.1246±0.03393		0.1216±0.02939		0.1102±0.02977
Testis(L)	0.3970±0.05812		0.3894±0.03277		0.3446±0.03651		0.3723±0.04046
Testis(R)	0.3855±0.04401		0.3913±0.02503*		0.3510±0.03787		0.3553±0.07024
Epididymis(L)	0.1459±0.01275		0.1415±0.01863		0.1269±0.00942		0.1389±0.01249
Epididymis(R)	0.1427±0.00921		0.1390±0.01379		0.1311±0.01601		0.1320±0.01853
Spleen	0.1955±0.02298	0.2184±0.01555	0.1975±0.02275	0.2385±0.02467	0.2036±0.02518	0.2238±0.02465	0.2039±0.02465	0.2382±0.02306
Kidney(L)	0.3124±0.02644	0.3052±0.02049	0.3054±0.02044	0.3172±0.01894	0.3220±0.02211	0.3279±0.02182	0.3433±0.01698*	0.3552±0.02969
Kidney(R)	0.3165±0.02627	0.3141±0.01792	0.3028±0.01658	0.3282±0.02604	0.3178±0.02394	0.3288±0.02064	0.3475±0.02013*	0.3524±0.02757
Heart	0.3010±0.01901	0.3304±0.02344	0.2960±0.01977	0.3444±0.03115	0.2944±0.00938	0.3476±0.01720	0.3018±0.01996	0.3411±0.02683
Lung	0.3589±0.02657	0.4505±0.02360	0.3660±0.04420	0.4737±0.03612	0.3641±0.03218	0.4642±0.02097	0.3626±0.01963	0.4606±0.02191
Brain	0.4566±0.03374	0.6917±0.05948	0.4336±0.03112	0.7079±0.05932	0.4222±0.02796	0.7027±0.05721	0.4383±0.02912	0.7182±0.04178
Liver	2.6053±0.18891	2.4522±0.21604	2.6860±0.13358	2.6201±0.15563	2.5971±0.17412	2.5198±0.22710	2.7464±0.17145	2.5577±0.21390
No. of animals	10	10	10	10	10	10	10	10

^*: Represents a significant difference at p<0.05 level compared with the vehicle control.
^**: Ratio (%): Relative ratio of organ weight against body weight
^#: The data shown represent means±S.D. (n=10).
%: Control group (G1), Low-dose group (G2: 1,250 mg/10 mL/day), Medium-dose group (G3: 2,500 mg/10 mL/day), High-dose group (G4: 5,000 mg/10 mL/day)